| Date | Location | Result | |
| May 26, 2022 | Charlotte, N.C. | Virginia Tech 18, Clemson 6 | Box score |
| May 24, 2022 | Charlotte, N.C. | North Carolina 9, Clemson 2 | Box score |
| May 21, 2022 | Clemson, S.C. | Clemson 5, Boston College 0 | Box score |
| May 20, 2022 | Clemson, S.C. | Clemson 6, Boston College 2 | Box score |
| May 19, 2022 | Clemson, S.C. | Clemson 15, Boston College 1 | Box score |
| May 17, 2022 | Conway, S.C. | Coastal Carolina 17, Clemson 2 | Box score |
| May 15, 2022 | Charlottesville, Va. | Virginia 6, Clemson 3 | Box score |
| May 15, 2022 | Charlottesville, Va. | Clemson 8, Virginia 2 | Box score |
| May 13, 2022 | Charlottesville, Va. | Virginia 11, Clemson 6 | Box score |
| May 10, 2022 | Columbia, S.C. | Coll. of Charleston 7, Clemson 5 | Box score |
| May 08, 2022 | Clemson, S.C. | Clemson 14, Georgia Tech 2 | Box score |
| May 07, 2022 | Clemson, S.C. | Clemson 12, Georgia Tech 9 | Box score |
| May 06, 2022 | Clemson, S.C. | Clemson 9, Georgia Tech 3 | Box score |
| May 01, 2022 | Louisville, Ky. | Louisville 18, Clemson 15 | Box score |
| Apr 30, 2022 | Louisville, Ky. | Louisville 10, Clemson 8 | Box score |
| Apr 29, 2022 | Louisville, Ky. | Louisville 7, Clemson 2 | Box score |
| Apr 27, 2022 | Clemson, S.C. | Clemson 17, Wofford 4 | Box score |
| Apr 26, 2022 | Clemson, S.C. | Clemson 12, Presbyterian 3 | Box score |
| Apr 24, 2022 | Clemson, S.C. | Clemson 8, Florida State 5 | Box score |
| Apr 23, 2022 | Clemson, S.C. | Florida State 4, Clemson 3 | Box score |
| Apr 22, 2022 | Clemson, S.C | Clemson 6, Florida State 4 | Box score |
| Apr 20, 2022 | Clemson, S.C. | Clemson 12, East Tennessee State 2 | Box score |
| Apr 19, 2022 | Athens, Ga. | Clemson 8, Georgia 4 | Box score |
| Apr 17, 2022 | Winston-Salem, N.C. | Clemson 10, Wake Forest 8 | Box score |
| Apr 16, 2022 | Winston-Salem, N.C. | Wake Forest 12, Clemson 9 | Box score |
| Apr 15, 2022 | Winston-Salem, N.C. | Clemson 1, Wake Forest 0 | Box score |
| Apr 12, 2022 | Greenville, S.C. | Clemson 11, USC Upstate 2 | Box score |
| Apr 10, 2022 | Notre Dame, Ind. | Notre Dame 9, Clemson 3 | Box score |
| Apr 09, 2022 | Notre Dame, Ind. | Notre Dame 8, Clemson 1 | Box score |
| Apr 08, 2022 | Notre Dame, Ind. | Notre Dame 4, Clemson 1 | Box score |
| Apr 05, 2022 | Clemson, S.C. | Clemson 4, Georgia 3 | Box score |
| Apr 03, 2022 | Clemson, S.C. | NC State 9, Clemson 7 | Box score |
| Apr 02, 2022 | Clemson, S.C. | NC State 5, Clemson 2 | Box score |
| Apr 01, 2022 | Clemson, S.C. | Clemson 14, NC State 3 | Box score |
| Mar 29, 2022 | Rock Hill, S.C. | Clemson 9, Winthrop 3 | Box score |
| Mar 25, 2022 | Pittsburgh, Pa. | Pittsburgh 10, Clemson 7 | Box score |
| Mar 25, 2022 | Pittsburgh, Pa. | Pittsburgh 8, Clemson 0 | Box score |
| Mar 23, 2022 | Clemson, S.C. | Clemson 10, Winthrop 2 | Box score |
| Mar 22, 2022 | Clemson, S.C. | Coastal Carolina 16, Clemson 7 | Box score |
| Mar 20, 2022 | Clemson, S.C. | Clemson 20, Miami (Fla.) 5 | Box score |
| Mar 19, 2022 | Clemson, S.C. | Miami (Fla.) 4, Clemson 1 | Box score |
| Mar 18, 2022 | Clemson, S.C. | Miami (Fla.) 11, Clemson 4 | Box score |
| Mar 15, 2022 | Clemson, S.C. | Georgia State 6, Clemson 1 | Box score |
| Mar 13, 2022 | Clemson, S.C. | Northeastern 5, Clemson 3 | Box score |
| Mar 12, 2022 | Clemson, S.C. | Clemson 10, Northeastern 4 | Box score |
| Mar 11, 2022 | Clemson, S.C. | Clemson 9, Northeastern 6 | Box score |
| Mar 09, 2022 | Greenville, S.C. | Clemson 4, Michigan State 2 | Box score |
| Mar 06, 2022 | Clemson, S.C. | Clemson 5, South Carolina 2 | Box score |
| Mar 05, 2022 | Columbia, S.C. | Clemson 10, South Carolina 2 | Box score |
| Mar 04, 2022 | Columbia, S.C. | Clemson 3, South Carolina 2 | Box score |
| Mar 01, 2022 | Clemson, S.C. | Clemson 8, USC Upstate 5 | Box score |
| Feb 26, 2022 | Clemson, S.C. | Clemson 28, Hartford 3 | Box score |
| Feb 26, 2022 | Clemson, S.C. | Clemson 13, Hartford 3 | Box score |
| Feb 25, 2022 | Clemson, S.C. | Clemson 6, Hartford 1 | Box score |
| Feb 22, 2022 | Clemson, S.C. | Clemson 2, Coll. of Charleston 1 | Box score |
| Feb 20, 2022 | Clemson, S.C. | Clemson 5, Indiana 4 | Box score |
| Feb 19, 2022 | Clemson, S.C. | Clemson 19, Indiana 4 | Box score |
| Feb 18, 2022 | Clemson, S.C. | Clemson 9, Indiana 0 | Box score |