| Date | Location | Result | |
| Nov 26, 2010 | Atlanta, Ga. | Georgia Tech 3, Clemson 2 (25-19,18-25,25-12,20-25,17-15) | Box score |
| Nov 20, 2010 | Raleigh, N.C. | Clemson 3, N.C. State 1 (30-28,22-25,25-21,25-17) | Box score |
| Nov 19, 2010 | Chapel Hill, N.C. | North Carolina 3, Clemson 0 (27-25,25-18,25-20) | Box score |
| Nov 13, 2010 | Clemson, SC | Clemson 3, Virginia Tech 1 (25-20,21-25,25-23,25-19) | Box score |
| Nov 12, 2010 | Clemson, SC | Clemson 3, Virginia 1 (23-25,25-16,29-27,25-21) | Box score |
| Nov 06, 2010 | Clemson, SC | Clemson 3, Florida State 0 (25-20,25-18,25-19) | Box score |
| Nov 05, 2010 | Clemson, SC | Miami 3, Clemson 1 (25-17,20-25,25-17,25-21) | Box score |
| Oct 30, 2010 | Winston-Salem, N.C. | Wake Forest 3, Clemson 1 (25-20,25-22,18-25,26-24) | Box score |
| Oct 29, 2010 | Durham, N.C. | Duke University 3, Clemson 1 (25-21,21-25,25-18,25-17) | Box score |
| Oct 23, 2010 | Clemson, SC | Clemson 3, Boston College 0 (25-21,25-11,25-15) | Box score |
| Oct 22, 2010 | Clemson, SC | Clemson 3, Maryland 1 (25-20,25-19,22-25,25-15) | Box score |
| Oct 16, 2010 | Clemson, SC | North Carolina 3, Clemson 1 (25-23,25-23,19-25,26-24) | Box score |
| Oct 15, 2010 | Clemson, SC | Clemson 3, N.C. State 2 (25-23,25-18,19-25,19-25,15-8) | Box score |
| Oct 10, 2010 | Coral Gables, Fla. | Miami 3, Clemson 1 (25-22,18-25,25-18,25-15) | Box score |
| Oct 08, 2010 | Tallahassee, Fla. | Florida State 3, Clemson 1 (21-25,25-19,25-12,25-21) | Box score |
| Oct 03, 2010 | Charlottesville, VA | Virginia 3, Clemson 2 (19-25,25-16,24-26,25-19,15-10) | Box score |
| Oct 01, 2010 | Blacksburg, Va. | Clemson 3, Virginia Tech 2 (25-20,18-25,25-20,21-25,15-11) | Box score |
| Sep 25, 2010 | Clemson, SC | Duke University 3, Clemson 2 (23-25,25-22,25-15,24-26,15-11) | Box score |
| Sep 24, 2010 | Clemson, SC | Wake Forest 3, Clemson 0 (28-26,26-24,25-23) | Box score |
| Sep 19, 2010 | Clemson, SC | Clemson 3, Florida A&M 0 (25-13,25-15,25-17) | Box score |
| Sep 18, 2010 | Clemson, SC | Clemson 3, Georgia State 0 (25-16,25-6,25-22) | Box score |
| Sep 17, 2010 | Clemson, SC | Clemson 3, Georgia Tech 2 (21-25,25-19,16-25,25-16,15-13) | Box score |
| Sep 11, 2010 | East Lansing, Mich. | Eastern Illinois 3, Clemson 1 (21-25,25-16,25-20,25-22) | Box score |
| Sep 11, 2010 | East Lansing, Mich. | Clemson 3, Eastern Michigan 1 (25-23,22-25,25-16,25-14) | Box score |
| Sep 10, 2010 | East Lansing, Mich. | Michigan State 3, Clemson 0 (25-22,25-16,25-20) | Box score |
| 09-04-10 | Rock Hill, SC | Clemson 3, Coll. of Charleston 2 (17-25,26-24,25-15,19-25,15-13) | Box score |
| 09-04-10 | Rock Hill, SC | Clemson 3, Winthrop 0 (30-28,25-16,25-17) | Box score |
| 09-03-10 | Rock Hill, SC | Clemson 3, South Carolina 0 (26-24,25-22,25-19) | Box score |
| Aug 28, 2010 | Clemson, SC | Clemson 3, Albany 0 (25-18,25-20,25-21) | Box score |
| Aug 28, 2010 | Clemson, SC | Clemson 3, Tennessee Tech 0 (25-13,25-12,25-18) | Box score |
| Aug 27, 2010 | Clemson, SC | Clemson 3, Jacksonville 0 (25-16,25-21,25-16) | Box score |